Electrochemistry

Biography

Biography: Vinita

Abstract

The advancement in the chemistry of the coordination polymers having designable architectures fabricated from functionalized building blocks is an emerging area from last two decades. The further challenges are the construction of coordination network assembly having electro-active nano-pores. We are first time exploring a nanocrystalline coordination polymer (NCCP) framework resulting from 2–amino–5–mercapto–1,3,4–thiadiazole (AMT)  and silver nitrate. In the infinite polymer arrangement of AMT–Ag, silver (I) centers are bridged by tecton AMT through the amino linkage and exocyclic thiol. The grasped nano–sized granules of AMT–Ag are investigated by FE-SEM. The crystalline nature along with the oxidation state of silver is studied through XRD, TEM and XPS respectively. Additionally, the thermal stability and activation energy for thermal decomposition of NCCP are scrutinized by thermo–gravimetric analysis. Furthermore, the efficient electron transfer kinetics is probed by using Fe (II)/Fe (III) redox couple in phosphate buffer pH 7 via cyclic voltammetry. The excellent electroactivity is employed in the electro-detection of a biologically active drug molecule ciprofloxacin hydrochloride (CFX). The anodic peak current revealed a linear dependence with CFX concentration with sensitivity and limit of detection as 0.001 μA/μM and 5.0 nM, respectively. The effective assay of the drug is caused by the excellent electron channeling through the pores of polymeric nano–crystallites. Further, the concept is extended and established in the voltammetric detection of CFX in biological fluid and pharmaceutical formulation by a considerably high sensitivity (0.002 mA/mM and 0.007 mA/mM) and the detection limit (22 nM and 60 nM) respectively. Our established system has potential for fabrication of high performance electro-chemical sensors for assay of biologically significant drug molecule.